Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3852422..3853068 Replicon chromosome
Accession NZ_CP110661
Organism Klebsiella pneumoniae strain B431

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag OOS97_RS18960 Protein ID WP_016529833.1
Coordinates 3852721..3853068 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag OOS97_RS18955 Protein ID WP_002920557.1
Coordinates 3852422..3852721 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS97_RS18935 (3848628) 3848628..3849386 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
OOS97_RS18940 (3849436) 3849436..3850266 - 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
OOS97_RS18945 (3850317) 3850317..3850646 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
OOS97_RS18950 (3850851) 3850851..3852359 + 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
OOS97_RS18955 (3852422) 3852422..3852721 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
OOS97_RS18960 (3852721) 3852721..3853068 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OOS97_RS18965 (3853244) 3853244..3855691 - 2448 WP_002920561.1 glycogen phosphorylase -
OOS97_RS18970 (3855709) 3855709..3857142 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T264108 WP_016529833.1 NZ_CP110661:c3853068-3852721 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT264108 WP_002920557.1 NZ_CP110661:c3852721-3852422 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References