264092

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2279992..2280594 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag OOK64_RS11305 Protein ID WP_001159630.1
Coordinates 2279992..2280303 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OOK64_RS11310 Protein ID WP_000362050.1
Coordinates 2280304..2280594 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS11270 (2275105) 2275105..2275704 + 600 WP_000965695.1 glucose-1-phosphatase -
OOK64_RS11275 (2275698) 2275698..2276570 + 873 WP_000921427.1 virulence factor BrkB family protein -
OOK64_RS11280 (2276567) 2276567..2277004 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
OOK64_RS11285 (2277049) 2277049..2277990 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OOK64_RS11290 (2278005) 2278005..2278451 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OOK64_RS11295 (2278448) 2278448..2278759 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OOK64_RS11300 (2278845) 2278845..2279774 - 930 WP_001127703.1 alpha/beta hydrolase -
OOK64_RS11305 (2279992) 2279992..2280303 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OOK64_RS11310 (2280304) 2280304..2280594 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OOK64_RS11315 (2280641) 2280641..2281570 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OOK64_RS11320 (2281567) 2281567..2282202 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OOK64_RS11325 (2282199) 2282199..2283101 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T264092 WP_001159630.1 NZ_CP110657:2279992-2280303 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT264092 WP_000362050.1 NZ_CP110657:2280304-2280594 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References