Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1874116..1874855 Replicon chromosome
Accession NZ_CP110621
Organism Pasteurella multocida strain P504190

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OO004_RS08900 Protein ID WP_015690952.1
Coordinates 1874116..1874442 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OO004_RS08905 Protein ID WP_015690953.1
Coordinates 1874529..1874855 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO004_RS08875 (OO004_08875) 1869421..1870107 + 687 WP_015690949.1 hypothetical protein -
OO004_RS08880 (OO004_08880) 1870173..1871702 - 1530 WP_015690950.1 YifB family Mg chelatase-like AAA ATPase -
OO004_RS08885 (OO004_08885) 1871810..1872427 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
OO004_RS08890 (OO004_08890) 1872538..1873407 + 870 WP_015690951.1 VirK/YbjX family protein -
OO004_RS08895 (OO004_08895) 1873482..1873958 - 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OO004_RS08900 (OO004_08900) 1874116..1874442 + 327 WP_015690952.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO004_RS08905 (OO004_08905) 1874529..1874855 + 327 WP_015690953.1 HigA family addiction module antitoxin Antitoxin
OO004_RS08910 (OO004_08910) 1874909..1876429 - 1521 WP_015690954.1 surface lipoprotein assembly modifier -
OO004_RS08915 (OO004_08915) 1876488..1877090 - 603 WP_015690955.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
OO004_RS08920 (OO004_08920) 1877177..1878127 - 951 WP_015690956.1 hypothetical protein -
OO004_RS08925 (OO004_08925) 1878366..1879400 - 1035 WP_015690957.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12919.76 Da        Isoelectric Point: 9.6705

>T264032 WP_015690952.1 NZ_CP110621:1874116-1874442 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLNDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12403.49 Da        Isoelectric Point: 7.2034

>AT264032 WP_015690953.1 NZ_CP110621:1874529-1874855 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKILSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References