Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1874073..1874812 Replicon chromosome
Accession NZ_CP110620
Organism Pasteurella multocida strain P5041881

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OO003_RS08935 Protein ID WP_015690952.1
Coordinates 1874073..1874399 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OO003_RS08940 Protein ID WP_015690953.1
Coordinates 1874486..1874812 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO003_RS08910 (OO003_08910) 1869378..1870064 + 687 WP_015690949.1 hypothetical protein -
OO003_RS08915 (OO003_08915) 1870130..1871659 - 1530 WP_015690950.1 YifB family Mg chelatase-like AAA ATPase -
OO003_RS08920 (OO003_08920) 1871767..1872384 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
OO003_RS08925 (OO003_08925) 1872495..1873364 + 870 WP_015690951.1 VirK/YbjX family protein -
OO003_RS08930 (OO003_08930) 1873439..1873915 - 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OO003_RS08935 (OO003_08935) 1874073..1874399 + 327 WP_015690952.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO003_RS08940 (OO003_08940) 1874486..1874812 + 327 WP_015690953.1 HigA family addiction module antitoxin Antitoxin
OO003_RS08945 (OO003_08945) 1874866..1876386 - 1521 WP_015690954.1 surface lipoprotein assembly modifier -
OO003_RS08950 (OO003_08950) 1876445..1877047 - 603 WP_015690955.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
OO003_RS08955 (OO003_08955) 1877134..1878084 - 951 WP_015690956.1 hypothetical protein -
OO003_RS08960 (OO003_08960) 1878323..1879357 - 1035 WP_015690957.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12919.76 Da        Isoelectric Point: 9.6705

>T264029 WP_015690952.1 NZ_CP110620:1874073-1874399 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLNDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12403.49 Da        Isoelectric Point: 7.2034

>AT264029 WP_015690953.1 NZ_CP110620:1874486-1874812 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKILSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References