Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3554177..3554847 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag M7V54_RS16885 Protein ID WP_003899954.1
Coordinates 3554177..3554521 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag M7V54_RS16890 Protein ID WP_003899955.1
Coordinates 3554518..3554847 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS16850 3549250..3550110 + 861 WP_003416628.1 alpha/beta hydrolase -
M7V54_RS16855 3550085..3550600 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
M7V54_RS16860 3550616..3550827 + 212 Protein_3329 (R)-hydratase -
M7V54_RS16865 3550840..3551133 + 294 WP_003416635.1 hypothetical protein -
M7V54_RS16870 3551421..3552710 + 1290 WP_003416640.1 ATP-binding protein -
M7V54_RS16875 3553057..3553491 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
M7V54_RS16880 3553494..3553946 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M7V54_RS16885 3554177..3554521 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M7V54_RS16890 3554518..3554847 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
M7V54_RS16895 3555084..3556345 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
M7V54_RS16900 3556567..3557828 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
M7V54_RS16905 3558101..3558448 + 348 WP_003899956.1 DUF2384 domain-containing protein -
M7V54_RS16910 3558445..3559065 + 621 WP_003899957.1 RES family NAD+ phosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T264022 WP_003899954.1 NZ_CP110619:3554177-3554521 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT264022 WP_003899955.1 NZ_CP110619:3554518-3554847 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References