Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2203291..2204159 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag M7V54_RS10315 Protein ID WP_010886136.1
Coordinates 2203291..2203668 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag M7V54_RS10320 Protein ID WP_003409886.1
Coordinates 2203710..2204159 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS10265 2199080..2199532 - 453 WP_003899095.1 lipoprotein -
M7V54_RS10270 2199596..2199997 + 402 WP_003409869.1 hypothetical protein -
M7V54_RS10275 2199990..2200172 - 183 WP_003409870.1 hypothetical protein -
M7V54_RS10280 2200286..2200636 - 351 WP_003899096.1 hypothetical protein -
M7V54_RS10285 2200647..2201549 - 903 WP_003899097.1 hypothetical protein -
M7V54_RS10290 2201570..2201761 - 192 WP_003409876.1 hypothetical protein -
M7V54_RS10295 2201762..2202058 - 297 WP_003409877.1 hypothetical protein -
M7V54_RS10300 2202298..2202513 + 216 WP_003409878.1 antitoxin -
M7V54_RS10305 2202510..2202821 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
M7V54_RS10310 2202795..2203316 - 522 WP_003904745.1 hypothetical protein -
M7V54_RS10315 2203291..2203668 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
M7V54_RS10320 2203710..2204159 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
M7V54_RS10325 2204156..2204701 + 546 WP_003409891.1 SecB-like chaperone -
M7V54_RS10330 2204590..2205204 - 615 WP_003901296.1 hypothetical protein -
M7V54_RS10335 2205253..2205549 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
M7V54_RS10340 2205546..2205797 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
M7V54_RS10345 2205784..2206278 + 495 WP_003899099.1 hypothetical protein -
M7V54_RS10350 2206438..2206845 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
M7V54_RS10355 2206849..2207121 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M7V54_RS10360 2207154..2208374 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T263998 WP_010886136.1 NZ_CP110619:2203291-2203668 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT263998 WP_003409886.1 NZ_CP110619:2203710-2204159 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References