Detailed information of TA system TA026394

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 938953..939647
• Replicon: chromosome
• Accession: NC_017265
• Organism: Yersinia pestis biovar Medievalis str. Harbin 35

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: YPC_RS04295
• Protein ID: WP_002214787.1
• Coordinates: 938953..939249 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: YPC_RS04300
• Protein ID: WP_002209924.1
• Coordinates: 939249..939647 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPC_RS04260	934075..935592	+	1518	WP_002209930.1	lysine--tRNA ligase	-
YPC_RS04270	936025..937239	+	1215	WP_002209929.1	tyrosine-type recombinase/integrase	-
YPC_RS04275	937321..937506	-	186	WP_002209928.1	hypothetical protein	-
YPC_RS04285	938104..938364	+	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
YPC_RS04290	938427..938789	+	363	WP_002209925.1	helix-turn-helix domain-containing protein	-
YPC_RS04295	938953..939249	+	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
YPC_RS04300	939249..939647	+	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
YPC_RS04305	940048..942339	-	2292	WP_002209923.1	toprim domain-containing protein	-
YPC_RS04310	942639..942965	+	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
YPC_RS24655	942958..943110	+	153	WP_002209921.1	hypothetical protein	-
YPC_RS04320	943124..943324	-	201	WP_002209920.1	AlpA family transcriptional regulator	-
YPC_RS04325	943506..943838	-	333	WP_002214791.1	hypothetical protein	-
YPC_RS04330	943844..944080	-	237	WP_002214792.1	hypothetical protein	-
YPC_RS04335	944093..944458	-	366	WP_002209919.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T26394 WP_002214787.1 NC_017265:938953-939249 [Yersinia pestis biovar Medievalis str. Harbin 35]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T26394 NC_017265:938953-939249 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT26394 WP_002209924.1 NC_017265:939249-939647 [Yersinia pestis biovar Medievalis str. Harbin 35]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT26394 NC_017265:939249-939647 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1