Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2962261..2962921 Replicon chromosome
Accession NZ_CP110533
Organism Enterobacter quasiroggenkampii strain WS12-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OM418_RS14040 Protein ID WP_048224499.1
Coordinates 2962568..2962921 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MX79
Locus tag OM418_RS14035 Protein ID WP_029741460.1
Coordinates 2962261..2962563 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM418_RS14015 (OM418_14015) 2958113..2960302 + 2190 WP_045908133.1 TonB-dependent siderophore receptor -
OM418_RS14025 (OM418_14025) 2960735..2961124 - 390 WP_277717817.1 RidA family protein -
OM418_RS14030 (OM418_14030) 2961266..2962186 + 921 WP_277717818.1 LysR family transcriptional regulator -
OM418_RS14035 (OM418_14035) 2962261..2962563 - 303 WP_029741460.1 XRE family transcriptional regulator Antitoxin
OM418_RS14040 (OM418_14040) 2962568..2962921 - 354 WP_048224499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM418_RS14045 (OM418_14045) 2963097..2963990 - 894 WP_277717819.1 LysR substrate-binding domain-containing protein -
OM418_RS14050 (OM418_14050) 2964161..2964769 + 609 WP_277717820.1 glutathione S-transferase family protein -
OM418_RS14055 (OM418_14055) 2964812..2965762 - 951 WP_262778175.1 HTH-type transcriptional regulator Cbl -
OM418_RS14060 (OM418_14060) 2965859..2966776 - 918 WP_045908128.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13519.37 Da        Isoelectric Point: 9.0310

>T263937 WP_048224499.1 NZ_CP110533:c2962921-2962568 [Enterobacter quasiroggenkampii]
VWAINTTDRFDRWFASLDDTDRASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
MLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11050.83 Da        Isoelectric Point: 5.7316

>AT263937 WP_029741460.1 NZ_CP110533:c2962563-2962261 [Enterobacter quasiroggenkampii]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MX79

References