Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 77439..78085 Replicon chromosome
Accession NZ_CP110533
Organism Enterobacter quasiroggenkampii strain WS12-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OM418_RS00350 Protein ID WP_277719131.1
Coordinates 77735..78085 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1H8WUL1
Locus tag OM418_RS00345 Protein ID WP_045352829.1
Coordinates 77439..77738 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM418_RS00315 (OM418_00315) 72839..73798 - 960 WP_262802363.1 DUF523 and DUF1722 domain-containing protein -
OM418_RS00320 (OM418_00320) 73901..74314 - 414 WP_048226512.1 hydroxyisourate hydrolase -
OM418_RS00325 (OM418_00325) 74414..75139 - 726 WP_048030818.1 MerR family transcriptional regulator -
OM418_RS00330 (OM418_00330) 75257..75781 + 525 WP_277718228.1 lipocalin family protein -
OM418_RS00335 (OM418_00335) 75860..76906 + 1047 WP_277718229.1 class I SAM-dependent methyltransferase -
OM418_RS00340 (OM418_00340) 76972..77409 + 438 WP_277718230.1 acetyltransferase -
OM418_RS00345 (OM418_00345) 77439..77738 - 300 WP_045352829.1 helix-turn-helix transcriptional regulator Antitoxin
OM418_RS00350 (OM418_00350) 77735..78085 - 351 WP_277719131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM418_RS00355 (OM418_00355) 78514..78855 - 342 WP_277718231.1 SymE family type I addiction module toxin -
OM418_RS00360 (OM418_00360) 78939..79079 + 141 WP_252077894.1 hypothetical protein -
OM418_RS00365 (OM418_00365) 79160..79972 + 813 WP_252077893.1 toll/interleukin-1 receptor domain-containing protein -
OM418_RS00375 (OM418_00375) 80363..81754 + 1392 WP_262752423.1 glycoside-pentoside-hexuronide family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 66667..79972 13305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13538.62 Da        Isoelectric Point: 9.6740

>T263929 WP_277719131.1 NZ_CP110533:c78085-77735 [Enterobacter quasiroggenkampii]
MWTVRFGKVFEQWLFEQEEGLQDKVLADLLNLQHYGPRLPRPYADTVKGSRYKHMKKLRIQYAGRPVPTFFAFDPVRQAI
VLCAGDKSNDKTFYEKMIRIADAEFSLHLTSQEAAK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11146.05 Da        Isoelectric Point: 8.0121

>AT263929 WP_045352829.1 NZ_CP110533:c77738-77439 [Enterobacter quasiroggenkampii]
VKTLNEVIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKKVADLMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H8WUL1

References