Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 755307..756082 Replicon chromosome
Accession NZ_CP110523
Organism Klebsiella pneumoniae strain WS_29-2

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag OM422_RS03795 Protein ID WP_009308645.1
Coordinates 755597..756082 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OM422_RS03790 Protein ID WP_004150912.1
Coordinates 755307..755600 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM422_RS03770 (750515) 750515..751117 - 603 WP_004174410.1 short chain dehydrogenase -
OM422_RS03775 (751215) 751215..752126 + 912 WP_016947442.1 LysR family transcriptional regulator -
OM422_RS03780 (752127) 752127..753275 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
OM422_RS03785 (753286) 753286..754662 - 1377 WP_016947440.1 cystathionine beta-synthase -
OM422_RS03790 (755307) 755307..755600 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OM422_RS03795 (755597) 755597..756082 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
OM422_RS03800 (756786) 756786..757379 + 594 WP_004188553.1 hypothetical protein -
OM422_RS03805 (757476) 757476..757692 + 217 Protein_747 transposase -
OM422_RS03815 (758370) 758370..759083 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 757476..757628 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T263894 WP_009308645.1 NZ_CP110523:755597-756082 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT263894 WP_004150912.1 NZ_CP110523:755307-755600 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References