Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 13609..14266 Replicon plasmid pRWS291.s4
Accession NZ_CP110518
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name higB Uniprot ID U3PDC3
Locus tag OM421_RS29700 Protein ID WP_000270043.1
Coordinates 13916..14266 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OM421_RS29695 Protein ID WP_000124640.1
Coordinates 13609..13911 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS29650 (OM421_29645) 9234..9662 + 429 WP_000591074.1 hypothetical protein -
OM421_RS29655 (OM421_29650) 9719..10078 + 360 WP_000422768.1 hypothetical protein -
OM421_RS29660 (OM421_29655) 10078..10524 + 447 WP_000919345.1 Fe3+-siderophore ABC transporter permease -
OM421_RS29665 (OM421_29660) 10521..11039 + 519 WP_000210756.1 nitrite reductase -
OM421_RS29670 (OM421_29665) 11039..11269 + 231 WP_000972663.1 hypothetical protein -
OM421_RS29675 (OM421_29670) 11256..12113 + 858 WP_001167032.1 hypothetical protein -
OM421_RS29680 (OM421_29675) 12344..12871 + 528 WP_001236377.1 thermonuclease family protein -
OM421_RS29685 (OM421_29680) 12929..13201 + 273 WP_001043047.1 HU family DNA-binding protein -
OM421_RS29690 (OM421_29685) 13289..13582 + 294 WP_001239997.1 chromosome segregation protein ParM -
OM421_RS29695 (OM421_29690) 13609..13911 - 303 WP_000124640.1 XRE family transcriptional regulator Antitoxin
OM421_RS29700 (OM421_29695) 13916..14266 - 351 WP_000270043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM421_RS29705 (OM421_29700) 14429..14977 + 549 WP_001061574.1 transcriptional regulator -
OM421_RS29710 (OM421_29705) 15318..15512 + 195 WP_000343597.1 hypothetical protein -
OM421_RS29715 (OM421_29710) 15523..15894 + 372 WP_000516916.1 hypothetical protein -
OM421_RS29720 (OM421_29715) 15887..16357 + 471 WP_001281821.1 hypothetical protein -
OM421_RS29725 (OM421_29720) 16372..16707 - 336 WP_000683476.1 hypothetical protein -
OM421_RS29730 (OM421_29725) 16804..17292 + 489 WP_001273096.1 DUF1643 domain-containing protein -
OM421_RS29735 (OM421_29730) 17295..17792 + 498 WP_000062185.1 hypothetical protein -
OM421_RS29740 (OM421_29735) 18007..18711 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
OM421_RS29745 (OM421_29740) 18776..18955 - 180 Protein_31 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / mph(A) / blaNDM-1 - 1..112292 112292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13328.21 Da        Isoelectric Point: 5.2421

>T263890 WP_000270043.1 NZ_CP110518:c14266-13916 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE

Download         Length: 351 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11006.73 Da        Isoelectric Point: 7.2036

>AT263890 WP_000124640.1 NZ_CP110518:c13911-13609 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G8AFB9

Antitoxin

Source ID Structure

References