Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3656606..3657405 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag OM087_RS17590 Protein ID WP_000347251.1
Coordinates 3656606..3657070 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag OM087_RS17595 Protein ID WP_001307405.1
Coordinates 3657070..3657405 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS17560 (3651607) 3651607..3652041 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
OM087_RS17565 (3652059) 3652059..3652937 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
OM087_RS17570 (3652927) 3652927..3653706 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
OM087_RS17575 (3653717) 3653717..3654190 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
OM087_RS17580 (3654213) 3654213..3655493 - 1281 WP_115723855.1 tagatose-bisphosphate aldolase subunit KbaZ -
OM087_RS17585 (3655742) 3655742..3656551 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OM087_RS17590 (3656606) 3656606..3657070 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OM087_RS17595 (3657070) 3657070..3657405 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OM087_RS17600 (3657554) 3657554..3659125 - 1572 WP_032181387.1 galactarate dehydratase -
OM087_RS17605 (3659500) 3659500..3660834 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
OM087_RS17610 (3660850) 3660850..3661620 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T263853 WP_000347251.1 NZ_CP110511:c3657070-3656606 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT263853 WP_001307405.1 NZ_CP110511:c3657405-3657070 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References