Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2854096..2854698 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag OM087_RS13660 Protein ID WP_000897305.1
Coordinates 2854387..2854698 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OM087_RS13655 Protein ID WP_000356397.1
Coordinates 2854096..2854386 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS13630 (2850041) 2850041..2850943 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
OM087_RS13635 (2850940) 2850940..2851575 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
OM087_RS13640 (2851572) 2851572..2852501 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
OM087_RS13645 (2852831) 2852831..2853073 - 243 WP_001086388.1 protein YiiF -
OM087_RS13650 (2853292) 2853292..2853510 - 219 WP_001295676.1 CopG family transcriptional regulator -
OM087_RS13655 (2854096) 2854096..2854386 - 291 WP_000356397.1 NadS family protein Antitoxin
OM087_RS13660 (2854387) 2854387..2854698 - 312 WP_000897305.1 hypothetical protein Toxin
OM087_RS13665 (2854927) 2854927..2855835 + 909 WP_001162704.1 alpha/beta hydrolase -
OM087_RS13670 (2855899) 2855899..2856840 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
OM087_RS13675 (2856885) 2856885..2857322 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
OM087_RS13680 (2857319) 2857319..2858191 - 873 WP_000920762.1 virulence factor BrkB family protein -
OM087_RS13685 (2858185) 2858185..2858784 - 600 WP_001295269.1 glucose-1-phosphatase -
OM087_RS13690 (2858883) 2858883..2859668 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T263851 WP_000897305.1 NZ_CP110511:c2854698-2854387 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT263851 WP_000356397.1 NZ_CP110511:c2854386-2854096 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References