Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3609147..3609792 Replicon chromosome
Accession NZ_CP110473
Organism Pantoea anthophila strain CL1

Toxin (Protein)


Gene name higB Uniprot ID A0A5M7PRL7
Locus tag OJ965_RS19350 Protein ID WP_046101034.1
Coordinates 3609439..3609792 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A855YNH6
Locus tag OJ965_RS19345 Protein ID WP_009092569.1
Coordinates 3609147..3609446 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ965_RS19330 (OJ965_19325) 3605052..3606836 - 1785 WP_046101035.1 GMC family oxidoreductase -
OJ965_RS19335 (OJ965_19330) 3606839..3607573 - 735 WP_009092567.1 gluconate 2-dehydrogenase subunit 3 family protein -
OJ965_RS19340 (OJ965_19335) 3607850..3609091 + 1242 WP_154928641.1 peptide antibiotic transporter SbmA -
OJ965_RS19345 (OJ965_19340) 3609147..3609446 - 300 WP_009092569.1 XRE family transcriptional regulator Antitoxin
OJ965_RS19350 (OJ965_19345) 3609439..3609792 - 354 WP_046101034.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OJ965_RS19355 (OJ965_19350) 3609989..3611041 - 1053 WP_265137512.1 YncE family protein -
OJ965_RS19360 (OJ965_19355) 3611241..3611450 - 210 WP_009092571.1 DUF1471 domain-containing protein -
OJ965_RS19365 (OJ965_19360) 3611663..3612850 - 1188 WP_265137513.1 MFS transporter -
OJ965_RS19370 (OJ965_19365) 3612955..3613932 + 978 WP_009092573.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13570.43 Da        Isoelectric Point: 5.2456

>T263838 WP_046101034.1 NZ_CP110473:c3609792-3609439 [Pantoea anthophila]
MWDIDTTHLFDEWFETQTEALKEDMLAAMIILSEYGPQLGRPYADTVDDSDFPNMKELRVQHQGNPIRAFFAFDPARRGI
VLCAGDKTGVKEKRFYKEMIKLADAEFRKHLKRGENG

Download         Length: 354 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11229.05 Da        Isoelectric Point: 8.6141

>AT263838 WP_009092569.1 NZ_CP110473:c3609446-3609147 [Pantoea anthophila]
MANLKELMAKQSPESRERIAEKVDEMRQVIALNMLREELNLSQTEMARAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVRLPTGKRIAFDL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M7PRL7

Antitoxin

Source ID Structure
AlphaFold DB A0A855YNH6

References