Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1669832..1670584 Replicon chromosome
Accession NZ_CP110473
Organism Pantoea anthophila strain CL1

Toxin (Protein)


Gene name higB Uniprot ID A0A506PAZ8
Locus tag OJ965_RS10255 Protein ID WP_072052719.1
Coordinates 1670249..1670584 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OJ965_RS10250 Protein ID WP_140028698.1
Coordinates 1669832..1670164 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ965_RS10225 (OJ965_10225) 1664834..1665223 + 390 WP_003849158.1 chemotaxis response regulator CheY -
OJ965_RS10230 (OJ965_10230) 1665233..1665874 + 642 WP_009089682.1 protein phosphatase CheZ -
OJ965_RS10235 (OJ965_10235) 1666066..1667217 + 1152 WP_046102008.1 flagellar biosynthesis protein FlhB -
OJ965_RS10240 (OJ965_10240) 1667210..1669309 + 2100 WP_046102007.1 flagellar biosynthesis protein FlhA -
OJ965_RS10245 (OJ965_10245) 1669309..1669701 + 393 WP_009089686.1 flagellar protein FlhE -
OJ965_RS10250 (OJ965_10250) 1669832..1670164 - 333 WP_140028698.1 HigA family addiction module antitoxin Antitoxin
OJ965_RS10255 (OJ965_10255) 1670249..1670584 - 336 WP_072052719.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OJ965_RS10260 (OJ965_10260) 1670636..1671634 - 999 WP_265139137.1 aldo/keto reductase -
OJ965_RS10265 (OJ965_10265) 1671870..1672787 - 918 WP_265139138.1 LysR substrate-binding domain-containing protein -
OJ965_RS10270 (OJ965_10270) 1672871..1674601 - 1731 WP_265139139.1 arginine--tRNA ligase -
OJ965_RS10275 (OJ965_10275) 1674813..1674935 - 123 WP_009089698.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-70)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12919.78 Da        Isoelectric Point: 9.7853

>T263835 WP_072052719.1 NZ_CP110473:c1670584-1670249 [Pantoea anthophila]
MIQGGHDVATLRNIDSFRDEWLRDFFLYGKHSGKIPMTLSSALARKLDIINAAVNYQDLRSPPGNRYEELNPPLKGYAAI
RVNEQYRLIFKWIDGKAVDLYLDPHSYKRHK

Download         Length: 336 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12545.45 Da        Isoelectric Point: 5.7134

>AT263835 WP_140028698.1 NZ_CP110473:c1670164-1669832 [Pantoea anthophila]
MNQATRKPTTVGDVLLYEYLEPAGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDVW
EVMHDARAQEEISRVTPLKMFLAQKENQVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A506PAZ8

Antitoxin

Source ID Structure

References