Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 537196..537704 Replicon plasmid pRho-G13
Accession NZ_CP110470
Organism Rhodococcus opacus strain G13

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ONE62_RS40735 Protein ID WP_265147908.1
Coordinates 537196..537456 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q0RYC5
Locus tag ONE62_RS40740 Protein ID WP_005569061.1
Coordinates 537453..537704 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONE62_RS40730 (ONE62_40720) 533549..536524 - 2976 WP_265147907.1 UPF0182 family protein -
ONE62_RS40735 (ONE62_40725) 537196..537456 - 261 WP_265147908.1 Txe/YoeB family addiction module toxin Toxin
ONE62_RS40740 (ONE62_40730) 537453..537704 - 252 WP_005569061.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ONE62_RS40745 (ONE62_40735) 537703..537927 + 225 WP_265147909.1 excalibur calcium-binding domain-containing protein -
ONE62_RS40750 (ONE62_40740) 537974..538414 - 441 WP_265147910.1 hypothetical protein -
ONE62_RS40755 (ONE62_40745) 539099..539395 - 297 Protein_518 rhodanese-like domain-containing protein -
ONE62_RS40760 (ONE62_40750) 539392..539658 - 267 WP_265147911.1 hypothetical protein -
ONE62_RS40765 (ONE62_40755) 539655..540110 - 456 WP_169695330.1 hypothetical protein -
ONE62_RS40770 (ONE62_40760) 540147..540566 - 420 WP_061696956.1 MarR family winged helix-turn-helix transcriptional regulator -
ONE62_RS40775 (ONE62_40765) 540821..540963 - 143 Protein_522 Lsr2 family protein -
ONE62_RS40780 (ONE62_40770) 541179..541634 - 456 WP_005563656.1 MaoC family dehydratase -
ONE62_RS40785 (ONE62_40775) 541631..542404 - 774 WP_005563657.1 3-oxoacyl-ACP reductase FabG -
ONE62_RS40790 (ONE62_40780) 542420..542640 - 221 Protein_525 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1100117 1100117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10404.79 Da        Isoelectric Point: 8.8638

>T263832 WP_265147908.1 NZ_CP110470:c537456-537196 [Rhodococcus opacus]
MKLVWDESAWEDYVWWQAQDRKIVKRIDTLLKDVERNGNDGIGKPEPLKHGFQGYWSRRITDEHRLAYKIVDDQIRIAAC
RYRYGH

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9358.50 Da        Isoelectric Point: 4.5216

>AT263832 WP_005569061.1 NZ_CP110470:c537704-537453 [Rhodococcus opacus]
MRTMTYSESRARYAEVLNAVVDDREEIVITRAGHEPVVMVSLDDYESLKETAYLLRSPENARRLLASIDRLESGGGTVRD
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q0RYC5

References