Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3697688..3698321 Replicon chromosome
Accession NZ_CP110469
Organism Rhodococcus opacus strain G13

Toxin (Protein)


Gene name graT Uniprot ID A0A3A9TJ70
Locus tag ONE62_RS17120 Protein ID WP_054248704.1
Coordinates 3697688..3697969 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ONE62_RS17125 Protein ID WP_007297375.1
Coordinates 3698028..3698321 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONE62_RS17100 (ONE62_17100) 3693654..3694541 - 888 WP_265147538.1 alpha/beta hydrolase -
ONE62_RS17105 (ONE62_17105) 3694791..3696269 - 1479 WP_265147448.1 FAD-dependent oxidoreductase -
ONE62_RS17110 (ONE62_17110) 3696537..3697025 - 489 WP_043782979.1 hypothetical protein -
ONE62_RS17115 (ONE62_17115) 3697314..3697445 + 132 WP_265147449.1 hypothetical protein -
ONE62_RS17120 (ONE62_17120) 3697688..3697969 + 282 WP_054248704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONE62_RS17125 (ONE62_17125) 3698028..3698321 + 294 WP_007297375.1 HigA family addiction module antitoxin Antitoxin
ONE62_RS17130 (ONE62_17130) 3698543..3699143 + 601 Protein_3388 recombinase family protein -
ONE62_RS17135 (ONE62_17135) 3699675..3699983 + 309 WP_205627428.1 hypothetical protein -
ONE62_RS17140 (ONE62_17140) 3700292..3701392 + 1101 WP_265147450.1 sulfatase-like hydrolase/transferase -
ONE62_RS17145 (ONE62_17145) 3701344..3701793 + 450 WP_265147451.1 hypothetical protein -
ONE62_RS17150 (ONE62_17150) 3702266..3702935 + 670 Protein_3392 enoyl-CoA hydratase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3692034..3693428 1394
- inside Genomic island - - 3694791..3730255 35464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-81)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11006.51 Da        Isoelectric Point: 8.9336

>T263829 WP_054248704.1 NZ_CP110469:3697688-3697969 [Rhodococcus opacus]
VIESFADKETERVFHRQFSKKLPQDIQRIARRRLLLIEAATDVNDLRVPPGNRLEKLSGDRLGQYSVRINDQYRICFIWR
ATAAYDVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10745.39 Da        Isoelectric Point: 7.0123

>AT263829 WP_007297375.1 NZ_CP110469:3698028-3698321 [Rhodococcus opacus]
MTTDLSPIHPGEILREDFLEPFGITQNRLATIIGVPPRRINEIVLGKRSITADTALRLAKAFGNSAQFWLNIQDRYELDL
AADKIGDALAKITRLSA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A9TJ70

Antitoxin

Source ID Structure

References