Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 24974..25632 Replicon plasmid pRBH2-5
Accession NZ_CP110467
Organism Acinetobacter baumannii strain RBH2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OMP06_RS20095 Protein ID WP_000312250.1
Coordinates 25273..25632 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OMP06_RS20090 Protein ID WP_001096429.1
Coordinates 24974..25273 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP06_RS20055 (OMP06_20055) 21033..21290 + 258 WP_071210684.1 hypothetical protein -
OMP06_RS20060 (OMP06_20060) 21295..21867 + 573 WP_071712043.1 hypothetical protein -
OMP06_RS20065 (OMP06_20065) 21843..22022 + 180 WP_002081921.1 hypothetical protein -
OMP06_RS20070 (OMP06_20070) 22039..22668 + 630 WP_071210686.1 hypothetical protein -
OMP06_RS20075 (OMP06_20075) 22708..23217 + 510 WP_001043200.1 hypothetical protein -
OMP06_RS20080 (OMP06_20080) 23298..23852 + 555 WP_000790086.1 hypothetical protein -
OMP06_RS20085 (OMP06_20085) 23902..24438 + 537 WP_000731980.1 hypothetical protein -
OMP06_RS20090 (OMP06_20090) 24974..25273 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
OMP06_RS20095 (OMP06_20095) 25273..25632 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMP06_RS20100 (OMP06_20100) 25833..26399 + 567 WP_000710385.1 hypothetical protein -
OMP06_RS20105 (OMP06_20105) 26448..26630 + 183 WP_000373385.1 hypothetical protein -
OMP06_RS20110 (OMP06_20110) 26697..27395 + 699 WP_000873190.1 hypothetical protein -
OMP06_RS20115 (OMP06_20115) 27534..27917 + 384 WP_071210698.1 hypothetical protein -
OMP06_RS20120 (OMP06_20120) 27978..28736 + 759 WP_071210697.1 hypothetical protein -
OMP06_RS20125 (OMP06_20125) 28787..29122 + 336 WP_071210696.1 hypothetical protein -
OMP06_RS20130 (OMP06_20130) 29989..30303 + 315 WP_071210660.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..124107 124107


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T263828 WP_000312250.1 NZ_CP110467:c25632-25273 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT263828 WP_001096429.1 NZ_CP110467:c25273-24974 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References