Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4259623..4260350 Replicon chromosome
Accession NZ_CP110404
Organism Shigella sonnei strain S17BD05200

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag OKF41_RS21460 Protein ID WP_000550189.1
Coordinates 4259623..4259937 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OKF41_RS21465 Protein ID WP_000560263.1
Coordinates 4259934..4260350 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF41_RS21440 (4255789) 4255789..4256775 - 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -
OKF41_RS21445 (4256854) 4256854..4257537 - 684 WP_001183060.1 vancomycin high temperature exclusion protein -
OKF41_RS21450 (4257614) 4257614..4258117 - 504 WP_001305117.1 M48 family metallopeptidase -
OKF41_RS21455 (4258202) 4258202..4259338 + 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
OKF41_RS21460 (4259623) 4259623..4259937 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
OKF41_RS21465 (4259934) 4259934..4260350 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
OKF41_RS21470 (4260395) 4260395..4262413 - 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
OKF41_RS21475 (4262639) 4262639..4264990 - 2352 WP_000695471.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T263819 WP_000550189.1 NZ_CP110404:4259623-4259937 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT263819 WP_000560263.1 NZ_CP110404:4259934-4260350 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References