Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3984020..3984747 Replicon chromosome
Accession NZ_CP110404
Organism Shigella sonnei strain S17BD05200

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag OKF41_RS20105 Protein ID WP_000547563.1
Coordinates 3984436..3984747 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OKF41_RS20100 Protein ID WP_000126296.1
Coordinates 3984020..3984439 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF41_RS20080 (3979071) 3979071..3979598 - 528 WP_001078766.1 electron transport protein HydN -
OKF41_RS20085 (3979746) 3979746..3980756 - 1011 WP_001402444.1 DNA-binding transcriptional regulator AscG -
OKF41_RS20090 (3981016) 3981016..3982473 + 1458 WP_001107890.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
OKF41_RS20095 (3982482) 3982482..3983906 + 1425 WP_000110319.1 6-phospho-beta-glucosidase AscB -
OKF41_RS20100 (3984020) 3984020..3984439 - 420 WP_000126296.1 helix-turn-helix domain-containing protein Antitoxin
OKF41_RS20105 (3984436) 3984436..3984747 - 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
OKF41_RS20110 (3984909) 3984909..3985682 - 774 WP_001026444.1 hypothetical protein -
OKF41_RS20115 (3985707) 3985707..3986177 - 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
OKF41_RS20120 (3986170) 3986170..3986580 - 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
OKF41_RS20125 (3986577) 3986577..3987344 - 768 WP_000067403.1 formate hydrogenlyase subunit HycG -
OKF41_RS20130 (3987344) 3987344..3987886 - 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
OKF41_RS20135 (3987896) 3987896..3989593 - 1698 WP_001288143.1 formate hydrogenlyase subunit HycE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T263816 WP_000547563.1 NZ_CP110404:c3984747-3984436 [Shigella sonnei]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.38 Da        Isoelectric Point: 4.3653

>AT263816 WP_000126296.1 NZ_CP110404:c3984439-3984020 [Shigella sonnei]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNQEFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References