Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1263085..1263626 Replicon chromosome
Accession NZ_CP110404
Organism Shigella sonnei strain S17BD05200

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag OKF41_RS06090 Protein ID WP_000615976.1
Coordinates 1263085..1263363 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag OKF41_RS06095 Protein ID WP_000729704.1
Coordinates 1263366..1263626 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF41_RS06075 (1260667) 1260667..1261245 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
OKF41_RS06080 (1261451) 1261451..1262218 + 768 WP_000333380.1 class II glutamine amidotransferase -
OKF41_RS06085 (1262189) 1262189..1262929 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OKF41_RS06090 (1263085) 1263085..1263363 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OKF41_RS06095 (1263366) 1263366..1263626 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OKF41_RS06100 (1263812) 1263812..1264585 + 774 WP_127148796.1 C40 family peptidase -
OKF41_RS06110 (1265626) 1265626..1265754 + 129 Protein_1176 ISAs1 family transposase -
OKF41_RS06115 (1265825) 1265825..1266322 + 498 WP_000006258.1 REP-associated tyrosine transposase RayT -
OKF41_RS06120 (1266445) 1266445..1268157 - 1713 Protein_1178 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 1252935..1266322 13387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T263807 WP_000615976.1 NZ_CP110404:c1263363-1263085 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT263807 WP_000729704.1 NZ_CP110404:c1263626-1263366 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References