Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4243137..4243864 Replicon chromosome
Accession NZ_CP110398
Organism Shigella sonnei strain S17BD06357

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag OKF40_RS21345 Protein ID WP_000550189.1
Coordinates 4243137..4243451 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OKF40_RS21350 Protein ID WP_000560263.1
Coordinates 4243448..4243864 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF40_RS21325 (4239303) 4239303..4240289 - 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -
OKF40_RS21330 (4240368) 4240368..4241051 - 684 WP_001183060.1 vancomycin high temperature exclusion protein -
OKF40_RS21335 (4241128) 4241128..4241631 - 504 WP_001305117.1 M48 family metallopeptidase -
OKF40_RS21340 (4241716) 4241716..4242852 + 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
OKF40_RS21345 (4243137) 4243137..4243451 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
OKF40_RS21350 (4243448) 4243448..4243864 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
OKF40_RS21355 (4243909) 4243909..4245927 - 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
OKF40_RS21360 (4246153) 4246153..4248504 - 2352 WP_000695471.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T263803 WP_000550189.1 NZ_CP110398:4243137-4243451 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT263803 WP_000560263.1 NZ_CP110398:4243448-4243864 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References