Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1263642..1264183 Replicon chromosome
Accession NZ_CP110398
Organism Shigella sonnei strain S17BD06357

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag OKF40_RS06085 Protein ID WP_000615976.1
Coordinates 1263642..1263920 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag OKF40_RS06090 Protein ID WP_000729704.1
Coordinates 1263923..1264183 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF40_RS06070 (1261224) 1261224..1261802 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
OKF40_RS06075 (1262008) 1262008..1262775 + 768 WP_000333380.1 class II glutamine amidotransferase -
OKF40_RS06080 (1262746) 1262746..1263486 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OKF40_RS06085 (1263642) 1263642..1263920 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OKF40_RS06090 (1263923) 1263923..1264183 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OKF40_RS06095 (1264369) 1264369..1265142 + 774 WP_127148796.1 C40 family peptidase -
OKF40_RS06105 (1266183) 1266183..1266311 + 129 Protein_1174 ISAs1 family transposase -
OKF40_RS06110 (1266382) 1266382..1266879 + 498 WP_000006258.1 REP-associated tyrosine transposase RayT -
OKF40_RS06115 (1267002) 1267002..1268714 - 1713 Protein_1176 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 1253492..1266879 13387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T263791 WP_000615976.1 NZ_CP110398:c1263920-1263642 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT263791 WP_000729704.1 NZ_CP110398:c1264183-1263923 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References