Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/DinJ(antitoxin) |
| Location | 1687156..1687789 | Replicon | chromosome |
| Accession | NC_017219 | ||
| Organism | Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | W6EYF0 |
| Locus tag | BLIJ_RS07965 | Protein ID | WP_012577854.1 |
| Coordinates | 1687156..1687524 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | B7GS37 |
| Locus tag | BLIJ_RS07970 | Protein ID | WP_012577855.1 |
| Coordinates | 1687505..1687789 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BLIJ_RS07920 | 1682786..1683043 | + | 258 | WP_012577847.1 | hypothetical protein | - |
| BLIJ_RS07925 | 1683040..1683531 | + | 492 | WP_012577848.1 | hypothetical protein | - |
| BLIJ_RS07930 | 1683677..1684081 | - | 405 | WP_014484963.1 | tyrosine-type recombinase/integrase | - |
| BLIJ_RS07935 | 1684078..1684338 | - | 261 | WP_012577849.1 | hypothetical protein | - |
| BLIJ_RS07940 | 1684493..1684837 | - | 345 | WP_012577850.1 | hypothetical protein | - |
| BLIJ_RS07945 | 1684968..1685339 | - | 372 | WP_012577851.1 | hypothetical protein | - |
| BLIJ_RS07950 | 1685446..1686201 | - | 756 | WP_012577852.1 | hypothetical protein | - |
| BLIJ_RS07955 | 1686198..1686425 | - | 228 | WP_014484964.1 | hypothetical protein | - |
| BLIJ_RS07960 | 1686422..1686967 | - | 546 | WP_012577853.1 | hypothetical protein | - |
| BLIJ_RS07965 | 1687156..1687524 | - | 369 | WP_012577854.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| BLIJ_RS07970 | 1687505..1687789 | - | 285 | WP_012577855.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| BLIJ_RS07975 | 1687865..1688164 | - | 300 | WP_012577856.1 | hypothetical protein | - |
| BLIJ_RS07980 | 1688252..1688434 | - | 183 | WP_014484966.1 | hypothetical protein | - |
| BLIJ_RS07985 | 1688434..1688775 | - | 342 | WP_012577857.1 | hypothetical protein | - |
| BLIJ_RS07990 | 1688777..1689562 | - | 786 | WP_012577858.1 | hypothetical protein | - |
| BLIJ_RS07995 | 1689761..1690102 | - | 342 | WP_012577859.1 | hypothetical protein | - |
| BLIJ_RS08000 | 1690216..1690560 | - | 345 | WP_014484967.1 | hypothetical protein | - |
| BLIJ_RS14615 | 1690557..1690718 | - | 162 | WP_155245937.1 | hypothetical protein | - |
| BLIJ_RS08005 | 1690808..1691422 | - | 615 | WP_012577862.1 | lysozyme | - |
| BLIJ_RS08010 | 1691635..1691862 | - | 228 | WP_025221588.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 1660718..1723279 | 62561 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13866.75 Da Isoelectric Point: 4.5746
>T26379 WP_012577854.1 NC_017219:c1687524-1687156 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
MTSTPSEPRLYDVWLMWVEFPDHPGIGKPRPVVITEVDGDLVSGIVAKITGNTDWDEAGDVPLLDWKAEGLLKPSLVRCS
QRFYFNRSELLQWFGRLSLRDAEHVNDGLEATLDIPPYRRSV
MTSTPSEPRLYDVWLMWVEFPDHPGIGKPRPVVITEVDGDLVSGIVAKITGNTDWDEAGDVPLLDWKAEGLLKPSLVRCS
QRFYFNRSELLQWFGRLSLRDAEHVNDGLEATLDIPPYRRSV
Download Length: 369 bp
>T26379 NC_017219:c1687524-1687156 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
ATGACCAGTACGCCAAGTGAACCGCGCCTGTATGACGTGTGGCTGATGTGGGTCGAGTTTCCCGACCATCCCGGTATCGG
CAAGCCGCGTCCCGTGGTAATCACCGAGGTTGACGGTGATCTGGTGTCGGGTATCGTGGCGAAGATAACCGGCAACACTG
ATTGGGATGAGGCCGGCGACGTGCCGCTGCTCGACTGGAAGGCCGAGGGGCTGTTGAAGCCGTCACTCGTGCGCTGTTCG
CAACGCTTCTACTTCAACAGGAGCGAACTGCTGCAATGGTTCGGACGACTCTCGTTGAGGGACGCGGAGCATGTTAACGA
CGGATTGGAAGCCACGTTGGACATTCCACCATACAGGCGGAGCGTATAG
ATGACCAGTACGCCAAGTGAACCGCGCCTGTATGACGTGTGGCTGATGTGGGTCGAGTTTCCCGACCATCCCGGTATCGG
CAAGCCGCGTCCCGTGGTAATCACCGAGGTTGACGGTGATCTGGTGTCGGGTATCGTGGCGAAGATAACCGGCAACACTG
ATTGGGATGAGGCCGGCGACGTGCCGCTGCTCGACTGGAAGGCCGAGGGGCTGTTGAAGCCGTCACTCGTGCGCTGTTCG
CAACGCTTCTACTTCAACAGGAGCGAACTGCTGCAATGGTTCGGACGACTCTCGTTGAGGGACGCGGAGCATGTTAACGA
CGGATTGGAAGCCACGTTGGACATTCCACCATACAGGCGGAGCGTATAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10472.80 Da Isoelectric Point: 5.0057
>AT26379 WP_012577855.1 NC_017219:c1687789-1687505 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
MGKLVANIDDDVKARAAALYDSMGMSLSTAVNMFLRQSLVDNGLPFKPTRHTPDGYPVPPVHNAYMFERSEKGHVILPAD
WNDSEDAVYDQYAK
MGKLVANIDDDVKARAAALYDSMGMSLSTAVNMFLRQSLVDNGLPFKPTRHTPDGYPVPPVHNAYMFERSEKGHVILPAD
WNDSEDAVYDQYAK
Download Length: 285 bp
>AT26379 NC_017219:c1687789-1687505 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
ATGGGTAAGCTGGTCGCCAATATCGATGATGATGTCAAGGCGCGTGCCGCCGCGCTCTACGATTCCATGGGCATGAGCCT
GAGCACCGCAGTCAACATGTTTTTACGCCAGTCTCTGGTGGACAACGGGTTGCCGTTCAAGCCGACGCGGCACACGCCGG
ACGGCTATCCGGTGCCGCCTGTTCACAATGCCTACATGTTCGAGCGTTCGGAGAAGGGCCATGTGATACTGCCCGCCGAT
TGGAATGATTCGGAGGATGCTGTCTATGACCAGTACGCCAAGTGA
ATGGGTAAGCTGGTCGCCAATATCGATGATGATGTCAAGGCGCGTGCCGCCGCGCTCTACGATTCCATGGGCATGAGCCT
GAGCACCGCAGTCAACATGTTTTTACGCCAGTCTCTGGTGGACAACGGGTTGCCGTTCAAGCCGACGCGGCACACGCCGG
ACGGCTATCCGGTGCCGCCTGTTCACAATGCCTACATGTTCGAGCGTTCGGAGAAGGGCCATGTGATACTGCCCGCCGAT
TGGAATGATTCGGAGGATGCTGTCTATGACCAGTACGCCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|