Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3486126..3486879 Replicon chromosome
Accession NZ_CP110395
Organism Paraburkholderia sp. D15

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LFL96_RS15020 Protein ID WP_280996001.1
Coordinates 3486126..3486407 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LFL96_RS15025 Protein ID WP_280996002.1
Coordinates 3486424..3486879 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFL96_RS15005 (LFL96_15010) 3481489..3482061 + 573 WP_280995998.1 TMEM165/GDT1 family protein -
LFL96_RS15010 (LFL96_15015) 3482247..3482948 - 702 WP_280995999.1 DUF4136 domain-containing protein -
LFL96_RS15015 (LFL96_15020) 3483187..3485907 + 2721 WP_280996000.1 aminopeptidase N -
LFL96_RS15020 (LFL96_15025) 3486126..3486407 + 282 WP_280996001.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LFL96_RS15025 (LFL96_15030) 3486424..3486879 + 456 WP_280996002.1 HigA family addiction module antitoxin Antitoxin
LFL96_RS15030 (LFL96_15035) 3486987..3488003 + 1017 WP_280996003.1 class 1 fructose-bisphosphatase -
LFL96_RS15040 (LFL96_15045) 3488247..3488447 - 201 WP_280996004.1 hypothetical protein -
LFL96_RS15045 (LFL96_15050) 3488572..3489480 - 909 WP_280996005.1 LysR family transcriptional regulator -
LFL96_RS15050 (LFL96_15055) 3489606..3490718 + 1113 WP_280996006.1 aldo/keto reductase -
LFL96_RS15055 (LFL96_15060) 3491253..3491402 + 150 WP_165614451.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10572.17 Da        Isoelectric Point: 7.8927

>T263786 WP_280996001.1 NZ_CP110395:3486126-3486407 [Paraburkholderia sp. D15]
MITTFGNKATAAIFEGKFVRSLPLNMQTLARRKLLMIDAADSVQNLHAPPGNRLESLQGDRCGQWSIRINTQWRICFHFV
EGEALNVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16621.10 Da        Isoelectric Point: 10.1337

>AT263786 WP_280996002.1 NZ_CP110395:3486424-3486879 [Paraburkholderia sp. D15]
MVIKRSELSGVDFSDVATGDNIPEIHPGEILRSEFLDPLGMSVNALALALRVPAPRINDVVRGKRAISADTALRLERYLG
ASAQFWLNLQIAYDLRVATAASGAQITREIEPMPKADRPKLPRMSPEHARAAALATSLRRDAEEERPRRKA

Download         Length: 456 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References