Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5042727..5043337 Replicon chromosome
Accession NZ_CP110389
Organism Rhodopseudomonas sp. P2A-2r

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ONR75_RS24395 Protein ID WP_265079519.1
Coordinates 5043044..5043337 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ONR75_RS24390 Protein ID WP_265079518.1
Coordinates 5042727..5043035 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR75_RS24370 (ONR75_24370) 5038279..5038881 - 603 WP_265083782.1 LysE family translocator -
ONR75_RS24375 (ONR75_24375) 5038887..5039759 - 873 WP_265079516.1 EamA family transporter -
ONR75_RS24380 (ONR75_24380) 5039782..5040324 - 543 WP_265079517.1 acetolactate synthase small subunit -
ONR75_RS24385 (ONR75_24385) 5040497..5042285 - 1789 Protein_4827 acetolactate synthase 3 large subunit -
ONR75_RS24390 (ONR75_24390) 5042727..5043035 - 309 WP_265079518.1 HigA family addiction module antitoxin Antitoxin
ONR75_RS24395 (ONR75_24395) 5043044..5043337 - 294 WP_265079519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONR75_RS24400 (ONR75_24400) 5043370..5044326 - 957 WP_265079520.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
ONR75_RS24405 (ONR75_24405) 5044304..5045195 + 892 Protein_4831 phosphoserine phosphatase SerB -
ONR75_RS24410 (ONR75_24410) 5045980..5047494 - 1515 WP_265079521.1 Do family serine endopeptidase -
ONR75_RS24415 (ONR75_24415) 5047674..5047874 - 201 WP_265079522.1 DUF2065 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5015246..5169233 153987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11524.98 Da        Isoelectric Point: 7.3193

>T263780 WP_265079519.1 NZ_CP110389:c5043337-5043044 [Rhodopseudomonas sp. P2A-2r]
MIVGFRDAWLRAFFVDDVRSRNIPADIESRLFRKLQMIDDATTDQDLRVPPSNHFEKLRGRLSGFHSIRINDQWRLIFRW
GGQGEASDIYLDDHSYR

Download         Length: 294 bp

>T263780 NZ_CP110389:c5043337-5043044 [Rhodopseudomonas sp. P2A-2r]
ATGATCGTGGGTTTTCGCGACGCATGGCTGCGGGCTTTCTTCGTAGACGATGTCCGCTCCCGGAATATTCCGGCAGACAT
CGAAAGCCGGCTGTTTCGTAAATTGCAGATGATCGATGACGCGACGACCGATCAGGATTTGCGCGTTCCGCCCAGCAATC
ATTTCGAGAAGCTGCGGGGCAGGCTGAGCGGCTTTCATTCGATTCGCATCAACGACCAATGGCGGCTGATCTTCCGGTGG
GGCGGCCAGGGTGAAGCGTCGGACATCTATCTGGACGATCACAGCTACCGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11366.24 Da        Isoelectric Point: 10.7364

>AT263780 WP_265079518.1 NZ_CP110389:c5043035-5042727 [Rhodopseudomonas sp. P2A-2r]
MVMTKRKPATVGEILVEEFMQPLGLTQAALAKAMGVQRKHVNELCNNRRSVTAATALILARVFGNGPDFWLNVQRRNDLW
EAMHSPQDLARIERATPLVNAA

Download         Length: 309 bp

>AT263780 NZ_CP110389:c5043035-5042727 [Rhodopseudomonas sp. P2A-2r]
ATGGTGATGACCAAGCGCAAGCCGGCGACGGTCGGCGAAATACTGGTAGAGGAATTCATGCAACCCCTTGGACTGACGCA
GGCGGCGTTGGCCAAGGCGATGGGCGTCCAGCGCAAGCATGTGAACGAACTGTGCAACAACCGTCGTAGTGTGACAGCGG
CGACGGCGCTCATTCTGGCGCGCGTTTTCGGCAATGGCCCGGACTTCTGGCTGAACGTGCAGCGCCGCAACGACCTCTGG
GAGGCGATGCACTCGCCGCAAGACCTTGCGCGGATCGAACGTGCGACGCCGTTGGTGAACGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References