Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 110809..111407 Replicon chromosome
Accession NZ_CP110372
Organism Proteus mirabilis strain CZP44

Toxin (Protein)


Gene name higB Uniprot ID I1YFL9
Locus tag ONR64_RS00470 Protein ID WP_001896384.1
Coordinates 111084..111407 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ONR64_RS00465 Protein ID WP_000058216.1
Coordinates 110809..111087 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR64_RS00450 (ONR64_00450) 107771..109591 + 1821 WP_000661889.1 conjugative transfer system coupling protein TraD -
ONR64_RS00455 (ONR64_00455) 109601..110161 + 561 WP_159262615.1 conjugative transfer protein -
ONR64_RS00460 (ONR64_00460) 110148..110783 + 636 WP_000033756.1 DUF4400 domain-containing protein -
ONR64_RS00465 (ONR64_00465) 110809..111087 - 279 WP_000058216.1 helix-turn-helix transcriptional regulator Antitoxin
ONR64_RS00470 (ONR64_00470) 111084..111407 - 324 WP_001896384.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONR64_RS00475 (ONR64_00475) 111588..111869 + 282 WP_000433891.1 type IV conjugative transfer system protein TraL -
ONR64_RS00480 (ONR64_00480) 111866..112492 + 627 WP_159262613.1 TraE/TraK family type IV conjugative transfer system protein -
ONR64_RS00485 (ONR64_00485) 112476..113372 + 897 WP_159262630.1 type-F conjugative transfer system secretin TraK -
ONR64_RS00490 (ONR64_00490) 113375..114664 + 1290 WP_159262611.1 TraB/VirB10 family protein -
ONR64_RS00495 (ONR64_00495) 114739..115311 + 573 WP_148039504.1 type IV conjugative transfer system lipoprotein TraV -
ONR64_RS00500 (ONR64_00500) 115308..115694 + 387 WP_032469918.1 TraA family conjugative transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) htpB 1294..204974 203680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12281.33 Da        Isoelectric Point: 9.7658

>T263750 WP_001896384.1 NZ_CP110372:c111407-111084 [Proteus mirabilis]
MSWKIDFYDGVEDQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGKHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Download         Length: 324 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10517.07 Da        Isoelectric Point: 9.9393

>AT263750 WP_000058216.1 NZ_CP110372:c111087-110809 [Proteus mirabilis]
MSLQKLKQRALANAEVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A244CN87

Antitoxin

Source ID Structure

References