Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3904041..3904638 Replicon chromosome
Accession NZ_CP110369
Organism Klebsiella pneumoniae isolate KP7626

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag OM094_RS19180 Protein ID WP_004142563.1
Coordinates 3904321..3904638 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag OM094_RS19175 Protein ID WP_004142561.1
Coordinates 3904041..3904328 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM094_RS19145 (3900122) 3900122..3900370 + 249 WP_002893037.1 DUF1158 domain-containing protein -
OM094_RS19150 (3900388) 3900388..3900729 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OM094_RS19155 (3900760) 3900760..3901875 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
OM094_RS19160 (3902054) 3902054..3902635 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
OM094_RS19165 (3902635) 3902635..3903003 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
OM094_RS19170 (3903123) 3903123..3903776 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
OM094_RS19175 (3904041) 3904041..3904328 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
OM094_RS19180 (3904321) 3904321..3904638 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM094_RS19185 (3904823) 3904823..3905866 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
OM094_RS19190 (3906533) 3906533..3907399 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
OM094_RS19195 (3907508) 3907508..3908935 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T263739 WP_004142563.1 NZ_CP110369:c3904638-3904321 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT263739 WP_004142561.1 NZ_CP110369:c3904328-3904041 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References