Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 323868..324454 Replicon chromosome
Accession NZ_CP110369
Organism Klebsiella pneumoniae isolate KP7626

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag OM094_RS01505 Protein ID WP_002920800.1
Coordinates 324086..324454 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag OM094_RS01500 Protein ID WP_004174006.1
Coordinates 323868..324089 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM094_RS01480 (320025) 320025..320951 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
OM094_RS01485 (320948) 320948..322225 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
OM094_RS01490 (322222) 322222..322989 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
OM094_RS01495 (322991) 322991..323704 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
OM094_RS01500 (323868) 323868..324089 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OM094_RS01505 (324086) 324086..324454 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OM094_RS01510 (324727) 324727..326043 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
OM094_RS01515 (326150) 326150..327037 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
OM094_RS01520 (327034) 327034..327879 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
OM094_RS01525 (327881) 327881..328951 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 320948..330032 9084


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T263731 WP_002920800.1 NZ_CP110369:324086-324454 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT263731 WP_004174006.1 NZ_CP110369:323868-324089 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References