Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3635650..3636325 Replicon chromosome
Accession NZ_CP110354
Organism Enterobacter hormaechei strain ECC2783

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OLI86_RS17610 Protein ID WP_032619177.1
Coordinates 3635650..3635949 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag OLI86_RS17615 Protein ID WP_015571639.1
Coordinates 3635960..3636325 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLI86_RS17590 (OLI86_17590) 3630782..3631399 - 618 WP_032634496.1 DUF1819 family protein -
OLI86_RS17595 (OLI86_17595) 3631563..3632531 - 969 WP_000654804.1 IS5-like element IS903B family transposase -
OLI86_RS17600 (OLI86_17600) 3632594..3634219 + 1626 WP_230199853.1 ATP-binding cassette domain-containing protein -
OLI86_RS17605 (OLI86_17605) 3634200..3635399 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
OLI86_RS17610 (OLI86_17610) 3635650..3635949 + 300 WP_032619177.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OLI86_RS17615 (OLI86_17615) 3635960..3636325 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
OLI86_RS17620 (OLI86_17620) 3636352..3637533 - 1182 WP_032619175.1 PLP-dependent aminotransferase family protein -
OLI86_RS17625 (OLI86_17625) 3637554..3638441 - 888 WP_032619173.1 LysR family transcriptional regulator -
OLI86_RS17630 (OLI86_17630) 3638539..3639141 + 603 WP_017382759.1 short chain dehydrogenase -
OLI86_RS17635 (OLI86_17635) 3639138..3639869 - 732 WP_017382760.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3631563..3632486 923
- inside Prophage - - 3631563..3657280 25717


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11564.19 Da        Isoelectric Point: 9.6776

>T263705 WP_032619177.1 NZ_CP110354:3635650-3635949 [Enterobacter hormaechei]
MINHSRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT263705 WP_015571639.1 NZ_CP110354:3635960-3636325 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References