Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 36286..37016 Replicon chromosome
Accession NZ_CP110354
Organism Enterobacter hormaechei strain ECC2783

Toxin (Protein)


Gene name higB Uniprot ID A0A837FIL2
Locus tag OLI86_RS00170 Protein ID WP_023302825.1
Coordinates 36286..36600 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OLI86_RS00175 Protein ID WP_032620773.1
Coordinates 36600..37016 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLI86_RS00150 (OLI86_00150) 31952..33037 + 1086 Protein_29 cellulase family glycosylhydrolase -
OLI86_RS00155 (OLI86_00155) 32943..34127 - 1185 WP_015570118.1 multidrug efflux MFS transporter EmrD -
OLI86_RS00160 (OLI86_00160) 34303..35136 - 834 WP_032620535.1 DMT family transporter -
OLI86_RS00165 (OLI86_00165) 35199..35645 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
OLI86_RS00170 (OLI86_00170) 36286..36600 + 315 WP_023302825.1 type II toxin-antitoxin system HigB family toxin Toxin
OLI86_RS00175 (OLI86_00175) 36600..37016 + 417 WP_032620773.1 helix-turn-helix domain-containing protein Antitoxin
OLI86_RS00180 (OLI86_00180) 37163..37261 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
OLI86_RS00185 (OLI86_00185) 37368..39056 + 1689 WP_023302827.1 acetolactate synthase large subunit -
OLI86_RS00190 (OLI86_00190) 39060..39347 + 288 WP_015570113.1 acetolactate synthase small subunit -
OLI86_RS00195 (OLI86_00195) 39473..40066 + 594 WP_003861054.1 transcriptional regulator UhpA -
OLI86_RS00200 (OLI86_00200) 40063..41568 + 1506 WP_032634219.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12415.51 Da        Isoelectric Point: 10.2825

>T263697 WP_023302825.1 NZ_CP110354:36286-36600 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15249.77 Da        Isoelectric Point: 5.2068

>AT263697 WP_032620773.1 NZ_CP110354:36600-37016 [Enterobacter hormaechei]
MIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANGPEIVALRKEMESVPVGI
AVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FIL2

Antitoxin

Source ID Structure

References