Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5514623..5515218 Replicon chromosome
Accession NZ_CP110353
Organism Pseudomonas aeruginosa strain PALA48

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA48_RS25885 Protein ID WP_071538299.1
Coordinates 5514940..5515218 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA48_RS25880 Protein ID WP_003123432.1
Coordinates 5514623..5514928 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA48_RS25845 (PALA48_05128) 5509763..5510611 + 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA48_RS25855 (PALA48_05130) 5510778..5511719 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA48_RS25860 (PALA48_05131) 5511836..5512450 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA48_RS25865 (PALA48_05132) 5512492..5513076 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA48_RS25870 (PALA48_05133) 5513117..5514217 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA48_RS25880 (PALA48_05135) 5514623..5514928 - 306 WP_003123432.1 HigA family addiction module antitoxin Antitoxin
PALA48_RS25885 5514940..5515218 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA48_RS25890 5515271..5515399 - 129 Protein_5114 integrase -
PALA48_RS25895 (PALA48_05136) 5515547..5517775 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA48_RS25900 (PALA48_05137) 5517845..5518492 - 648 WP_003095021.1 carbonate dehydratase -
PALA48_RS25905 (PALA48_05138) 5518554..5519792 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T263696 WP_071538299.1 NZ_CP110353:c5515218-5514940 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT263696 WP_003123432.1 NZ_CP110353:c5514928-5514623 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References