Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 725241..725836 Replicon chromosome
Accession NZ_CP110351
Organism Pseudomonas aeruginosa strain PALA45

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA45_RS03410 Protein ID WP_071538299.1
Coordinates 725241..725519 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA45_RS03415 Protein ID WP_003123432.1
Coordinates 725531..725836 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA45_RS03390 (PALA45_00678) 720667..721905 + 1239 WP_003113524.1 dipeptidase -
PALA45_RS03395 (PALA45_00679) 721967..722614 + 648 WP_003095021.1 carbonate dehydratase -
PALA45_RS03400 (PALA45_00680) 722684..724912 - 2229 WP_003113525.1 TonB-dependent receptor -
PALA45_RS03405 725060..725188 + 129 Protein_673 integrase -
PALA45_RS03410 725241..725519 + 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA45_RS03415 (PALA45_00681) 725531..725836 + 306 WP_003123432.1 HigA family addiction module antitoxin Antitoxin
PALA45_RS03425 (PALA45_00683) 726242..727342 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA45_RS03430 (PALA45_00684) 727383..727967 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA45_RS03435 (PALA45_00685) 728009..728623 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA45_RS03440 (PALA45_00686) 728740..729681 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA45_RS03450 (PALA45_00688) 729848..730696 - 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T263678 WP_071538299.1 NZ_CP110351:725241-725519 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT263678 WP_003123432.1 NZ_CP110351:725531-725836 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References