Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 69871..70466 Replicon chromosome
Accession NZ_CP110350
Organism Pseudomonas aeruginosa strain PALA44

Toxin (Protein)


Gene name higB Uniprot ID A0A9E8L6K5
Locus tag PALA44_RS00380 Protein ID WP_071534386.1
Coordinates 70188..70466 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA44_RS00375 Protein ID WP_003133769.1
Coordinates 69871..70176 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA44_RS00350 (PALA44_00071) 65144..67069 - 1926 WP_023085762.1 DUF3732 domain-containing protein -
PALA44_RS00355 67066..67533 - 468 WP_124075005.1 DUF6521 family protein -
PALA44_RS00360 67530..67901 - 372 WP_269973048.1 hypothetical protein -
PALA44_RS00365 (PALA44_00072) 67993..68424 - 432 WP_003460108.1 IS200/IS605 family transposase -
PALA44_RS00370 (PALA44_00073) 68364..69224 - 861 WP_269973049.1 hypothetical protein -
PALA44_RS00375 (PALA44_00074) 69871..70176 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA44_RS00380 70188..70466 - 279 WP_071534386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA44_RS00385 70519..70641 - 123 Protein_74 integrase -
PALA44_RS00390 (PALA44_00075) 70789..73017 + 2229 WP_034005476.1 TonB-dependent receptor -
PALA44_RS00395 (PALA44_00076) 73087..73734 - 648 WP_003095021.1 carbonate dehydratase -
PALA44_RS00400 (PALA44_00077) 73796..75034 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 67993..68424 431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10698.23 Da        Isoelectric Point: 7.9184

>T263671 WP_071534386.1 NZ_CP110350:c70466-70188 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMHHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT263671 WP_003133769.1 NZ_CP110350:c70176-69871 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References