Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6054569..6055164 Replicon chromosome
Accession NZ_CP110349
Organism Pseudomonas aeruginosa strain PALA40

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA40_RS28595 Protein ID WP_003117425.1
Coordinates 6054886..6055164 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA40_RS28590 Protein ID WP_003099268.1
Coordinates 6054569..6054874 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA40_RS28560 (PALA40_05635) 6050022..6050312 - 291 WP_023083237.1 DUF5447 family protein -
PALA40_RS28565 (PALA40_05636) 6050524..6050796 - 273 WP_003115921.1 hypothetical protein -
PALA40_RS28570 (PALA40_05637) 6050906..6051172 + 267 WP_016852153.1 hypothetical protein -
PALA40_RS28575 (PALA40_05638) 6051304..6052140 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
PALA40_RS28580 (PALA40_05639) 6052115..6053653 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
PALA40_RS28585 6053665..6054192 - 528 WP_071535723.1 ATP-binding protein -
PALA40_RS28590 (PALA40_05640) 6054569..6054874 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA40_RS28595 6054886..6055164 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA40_RS28600 6055217..6055345 - 129 Protein_5657 integrase -
PALA40_RS28605 (PALA40_05641) 6055493..6057721 + 2229 WP_003099265.1 TonB-dependent receptor -
PALA40_RS28610 (PALA40_05642) 6057791..6058438 - 648 WP_003095021.1 carbonate dehydratase -
PALA40_RS28615 (PALA40_05643) 6058500..6059738 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T263670 WP_003117425.1 NZ_CP110349:c6055164-6054886 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT263670 WP_003099268.1 NZ_CP110349:c6054874-6054569 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References