Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5223911..5224506 Replicon chromosome
Accession NZ_CP110347
Organism Pseudomonas aeruginosa strain PALA52

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA52_RS24125 Protein ID WP_071535843.1
Coordinates 5224228..5224506 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA52_RS24120 Protein ID WP_024947077.1
Coordinates 5223911..5224216 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA52_RS24090 5219870..5220160 - 291 WP_031627909.1 DUF5447 family protein -
PALA52_RS24095 (PALA52_04784) 5220336..5220608 - 273 WP_023086662.1 hypothetical protein -
PALA52_RS24100 (PALA52_04785) 5220718..5220984 + 267 WP_023088595.1 hypothetical protein -
PALA52_RS24105 5221040..5221375 + 336 WP_028680759.1 hypothetical protein -
PALA52_RS24110 (PALA52_04786) 5221495..5222928 - 1434 WP_020750803.1 hypothetical protein -
PALA52_RS24115 5223191..5223574 - 384 WP_003111574.1 hypothetical protein -
PALA52_RS24120 (PALA52_04787) 5223911..5224216 - 306 WP_024947077.1 HigA family addiction module antitoxin Antitoxin
PALA52_RS24125 5224228..5224506 - 279 WP_071535843.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA52_RS24130 5224559..5224681 - 123 Protein_4764 integrase -
PALA52_RS24135 (PALA52_04788) 5224835..5227063 + 2229 WP_121367217.1 TonB-dependent receptor -
PALA52_RS24140 (PALA52_04789) 5227134..5227781 - 648 WP_003095021.1 carbonate dehydratase -
PALA52_RS24145 (PALA52_04790) 5227843..5229081 - 1239 WP_121501150.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10674.25 Da        Isoelectric Point: 7.8937

>T263656 WP_071535843.1 NZ_CP110347:c5224506-5224228 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11244.76 Da        Isoelectric Point: 4.6081

>AT263656 WP_024947077.1 NZ_CP110347:c5224216-5223911 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLT
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References