Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1247718..1248340 Replicon chromosome
Accession NZ_CP110346
Organism Pseudomonas aeruginosa strain PALA35

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA35_RS05860 Protein ID WP_023910260.1
Coordinates 1247718..1248032 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA35_RS05865 Protein ID WP_263464183.1
Coordinates 1248035..1248340 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA35_RS05835 1242735..1243892 + 1158 Protein_1155 IS3 family transposase -
PALA35_RS05840 (PALA35_01167) 1244472..1245428 + 957 WP_263464185.1 site-specific integrase -
PALA35_RS05845 (PALA35_01168) 1245497..1245808 + 312 WP_031631670.1 outer membrane protein assembly factor BamE -
PALA35_RS05850 (PALA35_01169) 1245939..1246589 + 651 WP_263464184.1 BRCT domain-containing protein -
PALA35_RS05855 (PALA35_01170) 1246711..1247469 + 759 WP_033967231.1 KilA-N domain-containing protein -
PALA35_RS05860 (PALA35_01172) 1247718..1248032 + 315 WP_023910260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA35_RS05865 (PALA35_01173) 1248035..1248340 + 306 WP_263464183.1 helix-turn-helix domain-containing protein Antitoxin
PALA35_RS05870 (PALA35_01174) 1248401..1248703 - 303 WP_073665794.1 hypothetical protein -
PALA35_RS05875 (PALA35_01175) 1248700..1249413 - 714 WP_235175899.1 hypothetical protein -
PALA35_RS05880 (PALA35_01176) 1249410..1249601 - 192 WP_021205282.1 hypothetical protein -
PALA35_RS05885 (PALA35_01178) 1249857..1250285 - 429 WP_019486521.1 hypothetical protein -
PALA35_RS05890 (PALA35_01179) 1250330..1251166 - 837 WP_003085692.1 prohibitin family protein -
PALA35_RS05895 (PALA35_01180) 1251163..1251417 - 255 WP_003085694.1 hypothetical protein -
PALA35_RS05900 (PALA35_01181) 1251517..1251750 - 234 WP_123788651.1 hypothetical protein -
PALA35_RS05905 (PALA35_01182) 1251753..1252139 - 387 WP_123788652.1 LuxR C-terminal-related transcriptional regulator -
PALA35_RS05910 1252570..1253103 - 534 WP_071548365.1 PIN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1242863..1287371 44508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11776.54 Da        Isoelectric Point: 9.4385

>T263645 WP_023910260.1 NZ_CP110346:1247718-1248032 [Pseudomonas aeruginosa]
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR

Download         Length: 315 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11330.86 Da        Isoelectric Point: 7.2077

>AT263645 WP_263464183.1 NZ_CP110346:1248035-1248340 [Pseudomonas aeruginosa]
MDKELFAELVESVTQMDEIVRGERQPSREFHIDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References