Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5783103..5783698 Replicon chromosome
Accession NZ_CP110345
Organism Pseudomonas aeruginosa strain PALA30

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA30_RS27245 Protein ID WP_003113526.1
Coordinates 5783420..5783698 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag PALA30_RS27240 Protein ID WP_003111575.1
Coordinates 5783103..5783408 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA30_RS27205 (PALA30_05358) 5778244..5779092 + 849 WP_009878189.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA30_RS27215 (PALA30_05360) 5779259..5780200 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA30_RS27220 (PALA30_05361) 5780317..5780931 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
PALA30_RS27225 (PALA30_05362) 5780973..5781557 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA30_RS27230 (PALA30_05363) 5781598..5782698 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA30_RS27240 (PALA30_05365) 5783103..5783408 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
PALA30_RS27245 5783420..5783698 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA30_RS27250 5783751..5783879 - 129 Protein_5388 integrase -
PALA30_RS27255 (PALA30_05366) 5784027..5786255 + 2229 WP_034036795.1 TonB-dependent receptor -
PALA30_RS27260 (PALA30_05367) 5786325..5786972 - 648 WP_003095021.1 carbonate dehydratase -
PALA30_RS27265 (PALA30_05368) 5787034..5788272 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T263642 WP_003113526.1 NZ_CP110345:c5783698-5783420 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT263642 WP_003111575.1 NZ_CP110345:c5783408-5783103 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References