Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5077594..5078275 Replicon chromosome
Accession NZ_CP110345
Organism Pseudomonas aeruginosa strain PALA30

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag PALA30_RS23995 Protein ID WP_003111825.1
Coordinates 5077910..5078275 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA30_RS23990 Protein ID WP_003145733.1
Coordinates 5077594..5077917 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA30_RS23965 (PALA30_04717) 5073507..5074145 + 639 WP_003163192.1 hypothetical protein -
PALA30_RS23970 (PALA30_04718) 5074388..5074723 + 336 WP_003140884.1 TM2 domain-containing protein -
PALA30_RS23975 (PALA30_04719) 5074897..5075415 + 519 WP_003140886.1 PAAR domain-containing protein -
PALA30_RS23980 (PALA30_04720) 5075412..5076113 + 702 WP_003111822.1 VRR-NUC domain-containing protein -
PALA30_RS23985 (PALA30_04721) 5076130..5077218 + 1089 WP_058176146.1 DUF3396 domain-containing protein -
PALA30_RS23990 (PALA30_04722) 5077594..5077917 - 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
PALA30_RS23995 5077910..5078275 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA30_RS24000 5078539..5078778 - 240 WP_044060930.1 hypothetical protein -
PALA30_RS24005 (PALA30_04723) 5078985..5079257 + 273 WP_033954259.1 hypothetical protein -
PALA30_RS24010 (PALA30_04724) 5079288..5079713 - 426 WP_003116492.1 VOC family protein -
PALA30_RS24015 (PALA30_04725) 5079814..5080698 + 885 WP_033939105.1 LysR substrate-binding domain-containing protein -
PALA30_RS24020 (PALA30_04726) 5080671..5081624 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
PALA30_RS24025 (PALA30_04727) 5081845..5082279 + 435 WP_003114204.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5064524..5080698 16174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T263641 WP_003111825.1 NZ_CP110345:c5078275-5077910 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT263641 WP_003145733.1 NZ_CP110345:c5077917-5077594 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure

References