263630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2844899..2845494 Replicon chromosome
Accession NZ_CP110344
Organism Pseudomonas aeruginosa strain PALA24

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA24_RS13635 Protein ID WP_071536079.1
Coordinates 2844899..2845177 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA24_RS13640 Protein ID WP_003099268.1
Coordinates 2845189..2845494 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA24_RS13615 (PALA24_02711) 2840325..2841563 + 1239 WP_003113524.1 dipeptidase -
PALA24_RS13620 (PALA24_02712) 2841625..2842272 + 648 WP_003095021.1 carbonate dehydratase -
PALA24_RS13625 (PALA24_02713) 2842342..2844570 - 2229 WP_003121052.1 TonB-dependent receptor -
PALA24_RS13630 2844718..2844846 + 129 Protein_2688 integrase -
PALA24_RS13635 2844899..2845177 + 279 WP_071536079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA24_RS13640 (PALA24_02714) 2845189..2845494 + 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA24_RS13650 (PALA24_02716) 2846158..2846370 + 213 WP_021264081.1 AlpA family phage regulatory protein -
PALA24_RS13655 (PALA24_02717) 2846409..2847431 + 1023 WP_023109374.1 replication protein RepA -
PALA24_RS13660 (PALA24_02718) 2847986..2848420 - 435 WP_008175821.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
PALA24_RS13665 (PALA24_02719) 2848519..2849415 + 897 WP_031633678.1 cation transporter -
PALA24_RS13670 (PALA24_02720) 2849558..2850319 + 762 WP_009686175.1 ZIP family metal transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10632.17 Da        Isoelectric Point: 7.8937

>T263630 WP_071536079.1 NZ_CP110344:2844899-2845177 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT263630 WP_003099268.1 NZ_CP110344:2845189-2845494 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References