263629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2604858..2605486 Replicon chromosome
Accession NZ_CP110344
Organism Pseudomonas aeruginosa strain PALA24

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA24_RS12520 Protein ID WP_269971931.1
Coordinates 2605163..2605486 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8I0SEX5
Locus tag PALA24_RS12515 Protein ID WP_003116648.1
Coordinates 2604858..2605166 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA24_RS12495 (PALA24_02486) 2600536..2600844 + 309 Protein_2467 phosphate-starvation-inducible PsiE family protein -
PALA24_RS12500 (PALA24_02487) 2600831..2601793 + 963 WP_003116644.1 zinc metalloprotease HtpX -
PALA24_RS12505 (PALA24_02488) 2601813..2602964 + 1152 WP_003116645.1 trypsin-like peptidase domain-containing protein -
PALA24_RS12510 (PALA24_02489) 2603602..2604471 + 870 WP_003116646.1 LysR family transcriptional regulator -
PALA24_RS12515 (PALA24_02490) 2604858..2605166 - 309 WP_003116648.1 transcriptional regulator Antitoxin
PALA24_RS12520 2605163..2605486 - 324 WP_269971931.1 toxin Toxin
PALA24_RS12530 2606707..2607063 + 357 WP_269971923.1 hypothetical protein -
PALA24_RS12535 (PALA24_02493) 2607060..2607938 + 879 WP_010791768.1 hypothetical protein -
PALA24_RS12540 2608001..2608648 + 648 WP_269971924.1 hypothetical protein -
PALA24_RS12550 2609847..2610242 + 396 WP_269971925.1 restriction endonuclease -
PALA24_RS12555 2610247..2610459 + 213 WP_031684089.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2584504..2631102 46598
- inside IScluster/Tn - - 2599604..2615069 15465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-92)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12523.20 Da        Isoelectric Point: 10.1546

>T263629 WP_269971931.1 NZ_CP110344:c2605486-2605163 [Pseudomonas aeruginosa]
MSPFERNRKAHLDDDEYSLFQQMLLTNPEAGAVIANSGGLRKVRFGSVRRSKGKRGGVRVIYYYWHSGLQFWLFTLYDKD
ELDDLSSDQRRQLKALLEREVKARQTP

Download         Length: 324 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11604.36 Da        Isoelectric Point: 10.0927

>AT263629 WP_003116648.1 NZ_CP110344:c2605166-2604858 [Pseudomonas aeruginosa]
MTKRDIFSELIEGFDDLASAREGKRTLRTHKVEYKPIEPATGAEIVALREKLQMSQGVFAQAIHAKPATLKNWEQNRSKP
NDQATVLIRILNKHPDLIRELA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References