Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2730004..2730278 Replicon chromosome
Accession NZ_CP110289
Organism Enterococcus faecalis strain AKSZ-208

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag MZO28_RS13540 Protein ID WP_073340360.1
Coordinates 2730004..2730144 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2730077..2730278 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO28_RS13520 2725211..2726203 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
MZO28_RS13525 2726467..2727105 - 639 WP_073438309.1 lytic polysaccharide monooxygenase -
MZO28_RS13530 2727791..2729407 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -
MZO28_RS13535 2729736..2729885 + 150 WP_002411240.1 type I toxin-antitoxin system toxin PepG1 -
MZO28_RS13540 2730004..2730144 + 141 WP_073340360.1 putative holin-like toxin Toxin
- 2730077..2730278 - 202 - - Antitoxin
MZO28_RS13545 2730375..2730518 + 144 WP_073437820.1 putative holin-like toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-46)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T263575 WP_073340360.1 NZ_CP110289:2730004-2730144 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

Antitoxin


Download         Length: 202 bp

>AT263575 NZ_CP110289:c2730278-2730077 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6

Antitoxin

Download structure file

References