Detailed information of TA system TA263560

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2579577..2579834
• Replicon: chromosome
• Accession: NZ_CP110289
• Organism: Enterococcus faecalis strain AKSZ-208

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MZO28_RS12855
• Protein ID: WP_021164441.1
• Coordinates: 2579733..2579834 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2579577..2579784 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZO28_RS12830	2575261..2576214	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
MZO28_RS12835	2576253..2577008	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
MZO28_RS12840	2577005..2577970	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
MZO28_RS12845	2577967..2578914	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
MZO28_RS12850	2579099..2579551	+	453	WP_002389410.1	YueI family protein	-
-	2579577..2579784	+	208	-	-	Antitoxin
MZO28_RS12855	2579733..2579834	-	102	WP_021164441.1	putative holin-like toxin	Toxin
MZO28_RS12860	2580166..2580267	-	102	WP_075551663.1	putative holin-like toxin	-
MZO28_RS12865	2580457..2582727	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
MZO28_RS12870	2582898..2583398	+	501	WP_002372831.1	cysteine hydrolase family protein	-
MZO28_RS12875	2583797..2584693	+	897	WP_002389477.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T263560 WP_021164441.1 NZ_CP110289:c2579834-2579733 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT263560 NZ_CP110289:2579577-2579784 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin