Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4081836..4082563 Replicon chromosome
Accession NZ_CP110260
Organism Escherichia albertii strain KBSW16i

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag N6N74_RS20035 Protein ID WP_000547563.1
Coordinates 4081836..4082147 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N6N74_RS20040 Protein ID WP_000126297.1
Coordinates 4082144..4082563 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N74_RS20005 (4076978) 4076978..4078687 + 1710 WP_001288122.1 formate hydrogenlyase subunit HycE -
N6N74_RS20010 (4078697) 4078697..4079239 + 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
N6N74_RS20015 (4079239) 4079239..4080006 + 768 WP_000067396.1 formate hydrogenlyase subunit HycG -
N6N74_RS20020 (4080003) 4080003..4080413 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
N6N74_RS20025 (4080406) 4080406..4080876 + 471 WP_059219259.1 hydrogenase maturation peptidase HycI -
N6N74_RS20030 (4080919) 4080919..4081674 + 756 WP_113623175.1 hypothetical protein -
N6N74_RS20035 (4081836) 4081836..4082147 + 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
N6N74_RS20040 (4082144) 4082144..4082563 + 420 WP_000126297.1 helix-turn-helix domain-containing protein Antitoxin
N6N74_RS20045 (4082655) 4082655..4083083 - 429 WP_000536064.1 hypothetical protein -
N6N74_RS20050 (4083512) 4083512..4084039 + 528 WP_001078780.1 electron transport protein HydN -
N6N74_RS20055 (4084192) 4084192..4086444 + 2253 WP_044710912.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T263514 WP_000547563.1 NZ_CP110260:4081836-4082147 [Escherichia albertii]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15446.45 Da        Isoelectric Point: 4.4596

>AT263514 WP_000126297.1 NZ_CP110260:4082144-4082563 [Escherichia albertii]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References