Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 595184..595746 Replicon chromosome
Accession NZ_CP110260
Organism Escherichia albertii strain KBSW16i

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag N6N74_RS02960 Protein ID WP_000605679.1
Coordinates 595184..595462 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag N6N74_RS02965 Protein ID WP_000781370.1
Coordinates 595462..595746 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N74_RS02940 (591187) 591187..591618 - 432 WP_000152289.1 peroxiredoxin OsmC -
N6N74_RS02945 (591862) 591862..591999 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
N6N74_RS02950 (592156) 592156..593853 + 1698 WP_149992551.1 malate dehydrogenase -
N6N74_RS02955 (593988) 593988..594998 + 1011 WP_149992550.1 alcohol dehydrogenase AdhP -
N6N74_RS02960 (595184) 595184..595462 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6N74_RS02965 (595462) 595462..595746 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
N6N74_RS02970 (595974) 595974..596627 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
N6N74_RS02975 (596620) 596620..597504 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
N6N74_RS02980 (597517) 597517..600564 - 3048 WP_098402488.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T263505 WP_000605679.1 NZ_CP110260:595184-595462 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT263505 WP_000781370.1 NZ_CP110260:595462-595746 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References