Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2353726..2354288 Replicon chromosome
Accession NZ_CP110258
Organism Escherichia albertii strain KBSW50i

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag N6N69_RS11425 Protein ID WP_000605676.1
Coordinates 2353726..2354004 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag N6N69_RS11430 Protein ID WP_021528209.1
Coordinates 2354004..2354288 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N69_RS11405 (2349715) 2349715..2350146 - 432 WP_000152289.1 peroxiredoxin OsmC -
N6N69_RS11410 (2350404) 2350404..2350541 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
N6N69_RS11415 (2350698) 2350698..2352395 + 1698 WP_262930638.1 malate dehydrogenase -
N6N69_RS11420 (2352530) 2352530..2353540 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
N6N69_RS11425 (2353726) 2353726..2354004 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6N69_RS11430 (2354004) 2354004..2354288 + 285 WP_021528209.1 HigA family addiction module antitoxin Antitoxin
N6N69_RS11435 (2354516) 2354516..2355169 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
N6N69_RS11440 (2355162) 2355162..2356046 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
N6N69_RS11445 (2356059) 2356059..2359106 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T263488 WP_000605676.1 NZ_CP110258:2353726-2354004 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT263488 WP_021528209.1 NZ_CP110258:2354004-2354288 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure

References