Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4489859..4490613 | Replicon | chromosome |
| Accession | NZ_CP110220 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain MFDS1018147 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | OF824_RS21775 | Protein ID | WP_000558168.1 |
| Coordinates | 4489859..4490170 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OF824_RS21780 | Protein ID | WP_001259009.1 |
| Coordinates | 4490167..4490613 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OF824_RS21745 (4485517) | 4485517..4486419 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| OF824_RS21750 (4486416) | 4486416..4487051 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| OF824_RS21755 (4487048) | 4487048..4487977 | + | 930 | WP_000027736.1 | formate dehydrogenase accessory protein FdhE | - |
| OF824_RS21760 (4488024) | 4488024..4488314 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| OF824_RS21765 (4488315) | 4488315..4488626 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| OF824_RS21770 (4488844) | 4488844..4489773 | + | 930 | WP_001127705.1 | alpha/beta hydrolase | - |
| OF824_RS21775 (4489859) | 4489859..4490170 | + | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| OF824_RS21780 (4490167) | 4490167..4490613 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| OF824_RS21785 (4490628) | 4490628..4491569 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| OF824_RS21790 (4491614) | 4491614..4492051 | - | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| OF824_RS21795 (4492048) | 4492048..4492920 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| OF824_RS21800 (4492914) | 4492914..4493513 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| OF824_RS21805 (4493704) | 4493704..4494507 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| OF824_RS21810 (4494541) | 4494541..4495437 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T263451 WP_000558168.1 NZ_CP110220:4489859-4490170 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT263451 WP_001259009.1 NZ_CP110220:4490167-4490613 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|