Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4488024..4488626 Replicon chromosome
Accession NZ_CP110220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain MFDS1018147

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag OF824_RS21765 Protein ID WP_001159635.1
Coordinates 4488315..4488626 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OF824_RS21760 Protein ID WP_000362050.1
Coordinates 4488024..4488314 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF824_RS21745 (4485517) 4485517..4486419 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
OF824_RS21750 (4486416) 4486416..4487051 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OF824_RS21755 (4487048) 4487048..4487977 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
OF824_RS21760 (4488024) 4488024..4488314 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OF824_RS21765 (4488315) 4488315..4488626 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OF824_RS21770 (4488844) 4488844..4489773 + 930 WP_001127705.1 alpha/beta hydrolase -
OF824_RS21775 (4489859) 4489859..4490170 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
OF824_RS21780 (4490167) 4490167..4490613 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
OF824_RS21785 (4490628) 4490628..4491569 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OF824_RS21790 (4491614) 4491614..4492051 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
OF824_RS21795 (4492048) 4492048..4492920 - 873 WP_000921423.1 virulence factor BrkB family protein -
OF824_RS21800 (4492914) 4492914..4493513 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T263450 WP_001159635.1 NZ_CP110220:c4488626-4488315 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT263450 WP_000362050.1 NZ_CP110220:c4488314-4488024 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References