263429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1435834..1436398 Replicon chromosome
Accession NZ_CP110214
Organism Lacticaseibacillus paracasei strain ATG-E1

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag OKX02_RS07290 Protein ID WP_016363448.1
Coordinates 1436096..1436398 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag OKX02_RS07285 Protein ID WP_003570051.1
Coordinates 1435834..1436103 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKX02_RS07255 (OKX02_07255) 1430840..1431727 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
OKX02_RS07260 (OKX02_07260) 1431924..1433150 - 1227 WP_003570043.1 hypothetical protein -
OKX02_RS07265 (OKX02_07265) 1433348..1433752 + 405 WP_003570045.1 MerR family transcriptional regulator -
OKX02_RS07270 (OKX02_07270) 1433745..1434071 + 327 WP_003584272.1 YrdB family protein -
OKX02_RS07275 (OKX02_07275) 1434133..1434762 + 630 WP_265013399.1 DUF2399 domain-containing protein -
OKX02_RS07280 (OKX02_07280) 1434807..1435460 + 654 WP_003570049.1 N-acetyltransferase -
OKX02_RS07285 (OKX02_07285) 1435834..1436103 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OKX02_RS07290 (OKX02_07290) 1436096..1436398 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
OKX02_RS07295 (OKX02_07295) 1436737..1436880 + 144 WP_162259784.1 hypothetical protein -
OKX02_RS07300 (OKX02_07300) 1436998..1437690 + 693 WP_003570055.1 hypothetical protein -
OKX02_RS07305 (OKX02_07305) 1437926..1440103 + 2178 WP_003570057.1 Tex family protein -
OKX02_RS07310 (OKX02_07310) 1440528..1441085 - 558 WP_003584278.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T263429 WP_016363448.1 NZ_CP110214:1436096-1436398 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT263429 WP_003570051.1 NZ_CP110214:1435834-1436103 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References