Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4778480..4779082 Replicon chromosome
Accession NZ_CP110201
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-65

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag OCK73_RS23330 Protein ID WP_001159630.1
Coordinates 4778771..4779082 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OCK73_RS23325 Protein ID WP_000362050.1
Coordinates 4778480..4778770 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK73_RS23310 (4775973) 4775973..4776875 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OCK73_RS23315 (4776872) 4776872..4777507 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OCK73_RS23320 (4777504) 4777504..4778433 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OCK73_RS23325 (4778480) 4778480..4778770 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OCK73_RS23330 (4778771) 4778771..4779082 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OCK73_RS23335 (4779300) 4779300..4780229 + 930 WP_001127703.1 alpha/beta hydrolase -
OCK73_RS23340 (4780315) 4780315..4780626 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OCK73_RS23345 (4780623) 4780623..4781069 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OCK73_RS23350 (4781084) 4781084..4782025 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OCK73_RS23355 (4782070) 4782070..4782507 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
OCK73_RS23360 (4782504) 4782504..4783376 - 873 WP_000921427.1 virulence factor BrkB family protein -
OCK73_RS23365 (4783370) 4783370..4783969 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T263427 WP_001159630.1 NZ_CP110201:c4779082-4778771 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT263427 WP_000362050.1 NZ_CP110201:c4778770-4778480 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References